Natiijooyinka daraasadda ayaa muujisay in ragga qaata cirbadaha testosterone undecanoate ee muddada dheer ay aad ugu dheggan yihiin daaweynta ka dib sanadka 1 marka loo eego ragga qaata cirbadaha gaaban ee testosterone propionate.
Falanqaynta dib-u-eegista xogta laga helay in ka badan ragga 122,000 ee Maraykanka ayaa muujisay in ragga lagu daaweeyay testosterone undecanoate (Aveed, Endo Pharmaceuticals) waxay leeyihiin heerar isku mid ah oo u hoggaansamaya bilihii 6 ee ugu horreeya ee daaweynta sida ragga lagu daaweeyay cypionate testosterone.Heerarka u hoggaansamida waxay udhaxeeyeen 7 ilaa 12 bilood, iyada oo kaliya 8.2% bukaanada lagu daaweeyay cypionate testosterone sii wadida daaweynta bilaha 12 marka la barbardhigo 41.9% bukaanada lagu daaweeyay testosterone undecanoate.
"Caddaynta waxay soo jeedinaysaa in qaababka ku habboon ee daaweynta testosterone, sida cirbadaha muddada dheer, ay muhiim u yihiin rabitaanka ragga qaba yaraanta testosterone si ay u sii wadaan daaweynta," ayuu yiri Abraham Morgenthaler, MD, kaaliyaha borofisar qalliinka.Helio wuxuu sheegay inuu ka soo shaqeeyay waaxda kaadi mareenka ee Xarunta Caafimaadka ee Beth Israel Deaconess Medical School ee Dugsiga Caafimaadka Harvard."Waxaa jira aqoonsi sii kordhaya oo ah in yaraanta testosterone ay tahay xaalad caafimaad oo muhiim ah iyo in daaweynta testosterone ay hagaajin karto ma aha oo kaliya calaamadaha laakiin sidoo kale guud ahaan faa'iidooyinka caafimaadka sida hagaajinta kontoroolka sonkorta dhiigga, hoos u dhigista baruurta iyo korodhka murqaha, niyadda, lafaha cufnaanta iyo sabab aan la cayimin. .dhiig yaraan.Si kastaba ha ahaatee, faa'iidooyinkan waxaa la xaqiijin karaa oo keliya haddii raggu ku dhegaan daaweynta."
Morgenthaler iyo asxaabtiisuba waxay sameeyeen daraasad kooxeed dib-u-eegis ah oo ku saabsan xogta xogta Veradigm, oo ka kooban xogta diiwaanka caafimaadka elektaroonigga ah ee xarumaha bukaan-socodka ee Maraykanka, oo ay ku jiraan kuwa bilaabay testosterone undecanoate la isku duro ama testosterone cypionate inta u dhaxaysa 2014 iyo 2018. Ragga da'doodu tahay 18 iyo ka weyn.Xogta lagu soo ururiyey 6-bilood kordhinta laga bilaabo Juulaay 2019. Daaweynta dayactirka waxaa lagu qeexay inay tahay inta u dhaxaysa ballamaha oo aan ka badnayn laba jeer inta lagu taliyey muddada qiyaasta 20 ee testosterone undecanoate ama toddobaadyada 4 ee testosterone cypionate.U hoggaansanaanta daawaynta ayaa la qiimeeyay laga bilaabo taariikhda duritaanka koowaad ilaa taariikhda joojinta, beddelka daawada, ama dhamaadka daawaynta testosterone ee asal ahaan loo qoray.Testosterone aan u hoggaansanayn kooxda testosterone undecanoate waxaa lagu qeexay farqiga u dhexeeya maalmaha 42 ee u dhexeeya taariikhda dhammaadka ballanta koowaad iyo taariikhda bilawga ballanta labaad, ama farqiga u dhexeeya maalmaha 105 ee u dhexeeya ballamaha mustaqbalka.U hoggaansanaan la'aanta kooxda cypionate testosterone waxaa lagu qeexay in ka badan 21 maalmood inta u dhaxaysa dhammaadka hal ballan iyo bilawga xiga.Baarayaashu waxay qiimeeyeen isbeddelada miisaanka jidhka, BMI, cadaadiska dhiigga, heerarka testosterone, heerarka dhacdooyinka cusub ee wadnaha, iyo arrimaha khatarta ah ee bilaha 3 ka hor intaan la duri karin bilaha 12 ka dib bilawga daaweynta.
Kooxda daraasaddu waxay ka koobnayd 948 nin oo qaata testosterone undecanoate iyo 121,852 rag ah oo qaata testosterone cypionate.Marka la eego asalka, 18.9% ragga ee kooxda testosterone undecanoate iyo 41.2% ragga ee kooxda cypionate testosterone ma aysan helin ogaanshaha hypogonadism.Celceliska testosterone bilaashka ah ee asaasiga ah ayaa ka sarreeya bukaanada qaata testosterone undecanoate marka la barbardhigo kuwa qaata testosterone cypionate (65.2 pg / mL vs 38.8 pg / mL; P <0.001).
Intii lagu jiray 6dii bilood ee hore, heerarka u hoggaansanaantu waxay ahaayeen isku mid labada kooxoodba.Muddo 7 ilaa 12 bilood ah, kooxda testosterone undecanoate waxay lahayd heer aad u sarreeya marka loo eego kooxda cypionate testosterone (82% vs 40.8%; P <0.001).Marka la barbardhigo bilaha 12, saamiga sare ee ragga ee kooxda testosterone undecanoate ayaa sii waday daaweynta testosterone naive (41.9% vs 0.89.9%; P <0.001).Ragga qaata testosterone cypionate.
"Waxaa la yaab leh, kaliya 8.2 boqolkiiba ragga ku duray testosterone cypionate ayaa sii waday daaweynta ka dib 1 sano," ayuu yiri Morgenthaler."Qiimaha aadka u hooseeya ee daaweynta testosterone ee inta badan la isticmaalo ee Maraykanka waxay ka dhigan tahay in ragga testosterone-yar aan la daweyn."
Bukaan-socodka lagu daaweeyay testosterone undecanoate waxay lahaayeen isbeddel weyn oo isbeddel ah oo wadarta guud ee testosterone (171.7 ng / dl vs 59.6 ng / dl; P <0.001) iyo testosterone bilaash ah (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).Korodhka bilaha 12 marka la barbar dhigo bukaanada lagu daaweeyay cypionate testosterone.Testosterone undecanoate waxay muujisay kala duwanaansho yar oo wadarta heerarka testosterone marka loo eego cypionate testosterone.
Bilaha 12, celceliska isbeddelka miisaanka, BMI, iyo cadaadiska dhiigga ayaa la mid ah kooxaha dhexdooda.Kooxda testosterone undecanoate waxay lahayd saami aad u sarreeya oo ragga ah oo dhowaan la ogaaday cillad kacsi la'aan iyo cayil daba-gal ah, halka kooxda cypionate ee testosterone ay leedahay saami aad u sarreeya oo ragga ah oo lagu ogaado dhiig-karka, wadne xanuunka wadnaha, iyo xanuun joogto ah.
Cilmi-baaris dheeraad ah ayaa loo baahan yahay si loo fahmo sababta ragga intooda badan ee isku duro testosterone cypionate waxay joojiyaan daaweynta hal sano gudaheed, Morgenthaler ayaa sidaas leh.
"Waxaan u qaadan karnaa in daraasaddan, testosterone undecanoate loo isticmaalay qadar aad u sarreeya bilaha 12 sababtoo ah ku habboonaanta daroogada muddada dheer, laakiin si loo arko haddii tani ay sabab u tahay arrimo kale (sida kharashka), nacaybka irbado is-daaweyn oo isdaba joog ah, la'aanta horumar la taaban karo ee calaamadaha, ama sababo kale, "ayuu yiri Morgenthaler.
Waqtiga boostada: Jul-05-2023